Minimap2 requires an extra parameter for large reference (>4GB)
See minimap2 FAQ: https://github.com/lh3/minimap2/blob/master/FAQ.md#3-the-output-sam-doesnt-have-a-header And this issue: https://github.com/lh3/minimap2/issues/301
Minimap2 process would break with a large reference genome and requires to add --split-prefix or increase the -I parameter.