Improve HiFi binning
Different possibility to improve HiFi binning:
- Implement a circular aware startegy as in the Binning Pacbio Pipeline. Check on project if it would really improved the results
- Use of assembly graph: information of the assembly graph could be used to bin contigs : Check RepBin, https://github.com/metagentools/GraphBin2, GraphMB
- Use of methylation marks found in HiFi reads : check nanodisco use to do that with ONT reads. The methods was originally made for PacBio RS II data with the tool mbin. It is now possible to call methylation in HiFi reads so we could theoretically apply this method with our HiFi reads.