output.h 15 KB
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#ifndef _SPELL_BAYES_OUTPUT_H_
#define _SPELL_BAYES_OUTPUT_H_

#include <map>
#include <vector>
#include <string>
#include <iostream>
#include <fstream>
#include <cstring>

#include "eigen.h"
#include "error.h"
#include "generation_rs_fwd.h"

/** FOURCC **/

inline
bool check_fourcc(std::ifstream& ifs, const char* fourcc)
{
    char buf[4] = {0, 0, 0, 0};
    ifs.read(buf, 4);
    return strncmp(fourcc, buf, 4);
}

inline
void write_fourcc(std::ofstream& ofs, const char* fourcc)
{
    ofs.write(fourcc, 4);
}

/** SIZE_T **/

inline
void write_size(std::ofstream& ofs, size_t sz)
{
    ofs.write((const char*) &sz, sizeof sz);
}

inline
size_t read_size(std::ifstream& ifs)
{
    size_t ret;
    ifs.read((char*) &ret, sizeof ret);
    return ret;
}

/** STRING **/

inline
std::string read_str(std::ifstream& ifs)
{
    size_t sz = read_size(ifs);
    std::vector<char> tmp(sz);
    ifs.read(&tmp[0], sz);
    return {tmp.begin(), tmp.end()};
}

inline
void write_str(std::ofstream& ofs, const std::string& s)
{
    write_size(ofs, s.size());
    ofs.write(s.c_str(), s.size());
}

/** DOUBLE **/

inline
void write_double(std::ofstream& ofs, double sz)
{
    ofs.write((const char*) &sz, sizeof sz);
}

inline
double read_double(std::ifstream& ifs)
{
    double ret;
    ifs.read((char*) &ret, sizeof ret);
    return ret;
}

/** INT **/

inline
void write_int(std::ofstream& ofs, int sz)
{
    ofs.write((const char*) &sz, sizeof sz);
}

inline
int read_int(std::ifstream& ifs)
{
    int ret;
    ifs.read((char*) &ret, sizeof ret);
    return ret;
}

/** FAST_POLYNOM **/

inline
void write_fast_polynom(std::ofstream& ofs, const fast_polynom& fp)
{
    impl::f_polynom f = fp;
    write_int(ofs, fp.value);
    write_int(ofs, f.r_exp);
    write_int(ofs, f.s_exp);
    write_size(ofs, f.P.size());
    for (double c: f.P) {
        write_double(ofs, c);
    }
}

inline
fast_polynom read_fast_polynom(std::ifstream& ifs, int& original_key)
{
    original_key = read_int(ifs);
    impl::f_polynom ret = fast_polynom::zero;
    ret.r_exp = read_int(ifs);
    ret.s_exp = read_int(ifs);
    size_t sz = read_size(ifs);
    ret.P.resize(sz);
    for (size_t i = 0; i < sz; ++i) {
        ret.P[i] = read_double(ifs);
    }
    return ret;
}

/** ALGREBRAIC GENOTYPE **/

inline void write_algebraic_genotype(std::ofstream& ofs, const algebraic_genotype& ag)
{
    ofs.write((const char*) &ag.genotype, sizeof ag.genotype);
    ofs.write((const char*) &ag.type, sizeof ag.type);
    write_int(ofs, ag.poly.value);
}

inline algebraic_genotype read_algebraic_genotype(std::ifstream& ifs, const std::map<int, fast_polynom>& pt)
{
    algebraic_genotype ag;
    ifs.read((char*) &ag.genotype, sizeof ag.genotype);
    ifs.read((char*) &ag.type, sizeof ag.type);
    ag.poly = pt.find(read_int(ifs))->second;
    return ag;
}

/** GENOMATRIX **/

inline void write_genomatrix(std::ofstream& ofs, const GenoMatrix& mat)
{
    write_fourcc(ofs, "SGEM");
    /*std::map<decltype(fast_polynom::value), impl::f_polynom>*/
    std::set<fast_polynom> poly_table;
    for (int j = 0; j < mat.cols(); ++j) {
        for (int i = 0; i < mat.rows(); ++i) {
            poly_table.insert(mat(i, j).poly);
        }
    }
    write_size(ofs, poly_table.size());
    for (const auto& fp: poly_table) {
        write_fast_polynom(ofs, fp);
    }
    write_int(ofs, mat.cols());
    write_int(ofs, mat.rows());
    /*MSG_DEBUG("[write_genomatrix] cols=" << mat.cols() << " rows=" << mat.rows());*/
    for (int j = 0; j < mat.cols(); ++j) {
        for (int i = 0; i < mat.rows(); ++i) {
            /*write_int(ofs, mat(i, j).value);*/
            write_algebraic_genotype(ofs, mat(i, j));
        }
    }
}

inline
void read_genomatrix(std::ifstream& ifs, GenoMatrix& mat)
{
    if (check_fourcc(ifs, "SGEM")) {
        MSG_ERROR("File is not valid or has been corrupted", "");
        return;
    }
    std::map<int, fast_polynom> poly_map;

    size_t table_size = read_size(ifs);
    int key;

    for (size_t i = 0; i < table_size; ++i) {
        auto f = read_fast_polynom(ifs, key);
        poly_map[key] = f;
    }

    int cols = read_int(ifs);
    int rows = read_int(ifs);
    /*MSG_DEBUG("[read_genomatrix] cols=" << cols << " rows=" << rows);*/
    mat.resize(rows, cols);
    for (int j = 0; j < mat.cols(); ++j) {
        for (int i = 0; i < mat.rows(); ++i) {
            mat(i, j) = read_algebraic_genotype(ifs, poly_map);
        }
    }
}

/** GENERATION_RS **/

inline void write_generation_rs(std::ofstream& ofs, const generation_rs* gen)
{
    write_fourcc(ofs, "SGRS");
    write_str(ofs, gen->name);
    write_size(ofs, gen->P.size());
    for (const auto& p: gen->P) {
        write_double(ofs, p.weight);
        write_genomatrix(ofs, p.G.data);
    }
}

inline
generation_rs* read_generation_rs(std::ifstream& ifs)
{
    if (check_fourcc(ifs, "SGRS")) {
        MSG_ERROR("File is not valid or has been corrupted", "");
    }
    /*MSG_DEBUG("pouet 1"); MSG_QUEUE_FLUSH();*/
    std::string name = read_str(ifs);
    /*MSG_DEBUG("pouet 2"); MSG_QUEUE_FLUSH();*/
    generation_rs* ret = generation_rs::blank(name);
    /*MSG_DEBUG("pouet 3"); MSG_QUEUE_FLUSH();*/
    size_t n_p = read_size(ifs);
    /*MSG_DEBUG("Have " << n_p << " processes"); MSG_QUEUE_FLUSH();*/
    ret->P.resize(n_p);
    for (size_t i = 0; i < n_p; ++i) {
        ret->P[i].weight = read_double(ifs);
        GenoMatrix tmp;
        read_genomatrix(ifs, tmp);
        ret->P[i].G = convert(tmp);
        /*MSG_DEBUG("Read process");*/
        /*MSG_DEBUG(ret->P[i]);*/
    }
    ret->precompute();
    return ret;
}

/** MATRIX<SCALAR, R, C> **/

template <typename MATRIX_TYPE>
struct resize_matrix_impl;

template <> struct resize_matrix_impl<VectorXd> { void operator () (VectorXd& v, size_t rows, size_t) { v.resize(rows); } };
template <> struct resize_matrix_impl<MatrixXd> { void operator () (MatrixXd& m, size_t rows, size_t cols) { m.resize(rows, cols); } };

template <typename MATRIX_TYPE>
void resize_matrix(MATRIX_TYPE& m, size_t r, size_t c) { resize_matrix_impl<MATRIX_TYPE>()(m, r, c); }

template <typename SCALAR, int ROW, int COL, int C, int D, int E>
void read_matrix(std::ifstream& ifs, Eigen::Matrix<SCALAR, ROW, COL, C, D, E>& mat)
{
    size_t scalar_sz = read_size(ifs);
    if (scalar_sz != sizeof(SCALAR)) {
        MSG_ERROR("WRONG SIZE OF SCALAR, CAN'T READ FILE", "Make sure spell-marker and spell-qtl are always executed on machines with same word size.");
    }
    size_t n_row = read_size(ifs);
    size_t n_col = read_size(ifs);
    if (ROW != Eigen::Dynamic && ((int) n_row) != ROW) {
        MSG_ERROR("WRONG ROW COUNT. FILE IS NOT A LOCUS VECTOR FILE OR IS CORRUPTED", "You may want to run spell-marker again");
    }
    if (COL != Eigen::Dynamic && ((int) n_col) != COL) {
        MSG_ERROR("WRONG COLUMN COUNT. FILE IS NOT A LOCUS VECTOR FILE OR IS CORRUPTED", "You may want to run spell-marker again");
    }
    resize_matrix(mat, n_row, n_col);
    ifs.read((char*) mat.data(), n_row * n_col * sizeof(SCALAR));
}

template <typename SCALAR, int ROW, int COL, int C, int D, int E>
void write_matrix(std::ofstream& ofs, const Eigen::Matrix<SCALAR, ROW, COL, C, D, E>& mat)
{
    write_size(ofs, sizeof(SCALAR));
    write_size(ofs, mat.rows());
    write_size(ofs, mat.cols());
    ofs.write((const char*) mat.data(), mat.size() * sizeof(SCALAR));
}


/** **/


struct LV_database {
    std::map<std::string, std::map<std::string, std::vector<MatrixXd>>> data;

    LV_database() : data() {}
    
    MatrixXd& operator () (const std::string& chr, const std::string& gen, size_t ind)
    {
        return data[chr][gen][ind];
    }

    const MatrixXd& operator () (const std::string& chr, const std::string& gen, size_t ind) const
    {
        return data.find(chr)->second.find(gen)->second[ind];
    }

    static
        bool lv_check_fourcc(std::ifstream& ifs, const char* fourcc)
        {
            if (check_fourcc(ifs, fourcc)) {
                MSG_ERROR("FILE IS NOT A LOCUS VECTOR FILE OR IS CORRUPTED", "You may want to run spell-marker again.");
                return true;
            }
            return false;
        }

    static
        LV_database load_from(const std::string& filename)
        {
            std::ifstream ifs(filename);
            return load_from(ifs);
        }

    static
        LV_database load_from(std::ifstream& ifs)
        {
            LV_database LV;

            if (lv_check_fourcc(ifs, "SMLV")) { return {}; }
            size_t n_chrom = read_size(ifs);
            size_t n_gen = read_size(ifs);
            for (size_t c = 0; c < n_chrom; ++c) {
                if (lv_check_fourcc(ifs, "SCHR")) { return {}; }
                std::string chr_name = read_str(ifs);
                for (size_t g = 0; g < n_gen; ++g) {
                    if (lv_check_fourcc(ifs, "SGEN")) { return {}; }
                    std::string gen_name = read_str(ifs);
                    size_t n_ind = read_size(ifs);
                    LV.data[chr_name][gen_name].resize(n_ind);
                    for (size_t i = 0; i < n_ind; ++i) {
                        if (lv_check_fourcc(ifs, "SLV_")) { return {}; }
                        read_matrix(ifs, LV.data[chr_name][gen_name][i]);
                    }
                }
            }
            return LV;
        }

    void save_to(const std::string& filename)
    {
        std::ofstream ofs(filename);
        save_to(ofs);
    }

    void save_to(std::ofstream& ofs)
    {
        write_fourcc(ofs, "SMLV");
        write_size(ofs, data.size());
        write_size(ofs, data.begin()->second.size());
        for (const auto& chr_gen_vec_lv: data) {
            write_fourcc(ofs, "SCHR");
            write_str(ofs, chr_gen_vec_lv.first);
            for (const auto& gen_vec_lv: chr_gen_vec_lv.second) {
                write_fourcc(ofs, "SGEN");
                write_str(ofs, gen_vec_lv.first);
                write_size(ofs, gen_vec_lv.second.size());
                for (const auto& lv: gen_vec_lv.second) {
                    write_fourcc(ofs, "SLV_");
                    write_matrix(ofs, lv);
                }
            }
        }
    }

    friend
        std::ostream& operator << (std::ostream& os, const LV_database& LV)
        {
            for (const auto& chr_gen_vec_lv: LV.data) {
                MSG_DEBUG("CHROMOSOME " << chr_gen_vec_lv.first);
                for (const auto& gen_vec_lv: chr_gen_vec_lv.second) {
                    MSG_DEBUG("* generation " << gen_vec_lv.first);
                    size_t i = 0;
                    for (const auto& lv: gen_vec_lv.second) {
                        MSG_DEBUG("  #" << i);
                        ++i;
                        MSG_DEBUG(lv);
                    }
                }
            }
            return os;
        }
};


/** **/


struct pop_data_type {
    std::string name;
    std::map<std::string, std::string> marker_observation_filenames;
    std::string genetic_map_filename;
    std::string pedigree_filename;
    std::string qtl_generation_name;
    std::map<std::string, generation_rs*> generations;
    LV_database LV;

    std::string save()
    {
        static const char* forbidden = ":?*/\\";
        std::stringstream filename;
        for (char c: name) {
            if (strchr(forbidden, c)) {
                filename << '_';
            } else {
                filename << c;
            }
        }
        filename << ".popdata";
        save_to(filename.str());
        return filename.str();
    }

    void save_to(const std::string& filename)
    {
        std::ofstream ofs(filename);
        write_fourcc(ofs, "SPOP");
        write_str(ofs, name);
        write_size(ofs, marker_observation_filenames.size());
        for (const auto& kv: marker_observation_filenames) {
            write_str(ofs, kv.first);
            write_str(ofs, kv.second);
        }
        write_str(ofs, genetic_map_filename);
        write_str(ofs, pedigree_filename);
        write_str(ofs, qtl_generation_name);
        write_size(ofs, generations.size());
        for (const auto& kv: generations) {
            write_fourcc(ofs, "SGTE");
            write_str(ofs, kv.first);
            write_generation_rs(ofs, kv.second);
        }
        LV.save_to(ofs);
    }

    static
        pop_data_type load_from(const std::string& filename)
        {
            std::ifstream ifs(filename);
            pop_data_type ret;
            if (check_fourcc(ifs, "SPOP")) {
                MSG_ERROR("This is not a valid population data file.", "");
                return ret;
            }
            ret.name = read_str(ifs);
            size_t n_mof = read_size(ifs);
            for (size_t i = 0; i < n_mof; ++i) {
                std::string k = read_str(ifs);
                std::string v = read_str(ifs);
                ret.marker_observation_filenames[k] = v;
            }
            ret.genetic_map_filename = read_str(ifs);
            ret.pedigree_filename = read_str(ifs);
            ret.qtl_generation_name = read_str(ifs);
            size_t n_gen = read_size(ifs);
            for (size_t i = 0; i < n_gen; ++i) {
                if (check_fourcc(ifs, "SGTE")) {
                    MSG_ERROR("This is not a valid population data file.", "");
                    return ret;
                }
                std::string k = read_str(ifs);
                MSG_DEBUG("*** reading generation " << k);
                MSG_QUEUE_FLUSH();
                ret.generations[k] = read_generation_rs(ifs);
                MSG_DEBUG("*** done"); MSG_QUEUE_FLUSH();
            }
            ret.LV = LV_database::load_from(ifs);
            return ret;
        }

    template <typename PRINTABLE>
    static
        void prepend(std::ostream& os, const std::string& pfx, PRINTABLE&& p)
        {
            std::stringstream ss;
            ss << p;
            while (!ss.eof()) {
                std::string line;
                std::getline(ss, line);
                os << pfx << line << std::endl;
            }
        }

    friend
        std::ostream& operator << (std::ostream& os, const pop_data_type& pop_data)
        {
            os << "POPULATION " << pop_data.name << std::endl
               << "| QTL generation: " << pop_data.qtl_generation_name << std::endl
               << "| Marker observations:" << std::endl;
            for (const auto& kv: pop_data.marker_observation_filenames) {
                os << "| - " << kv.first << ": " << kv.second << std::endl;
            }
            os << "| Generation matrices:" << std::endl;
            for (const auto& kv: pop_data.generations) {
                prepend(os, "|   ", (*kv.second));
            }
            os << "| Computed locus vectors:" << std::endl;
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            /*prepend(os, "| ", pop_data.LV);*/
            for (const auto& kv: pop_data.LV.data) {
                os << "| Chromosome " << kv.first << std::endl;
                for (const auto& gen_lv: kv.second) {
                    os << "|   Generation " << gen_lv.first << std::endl;
                    for (size_t i = 0; i < gen_lv.second.size(); ++i) {
                        os << "|     #" << i << std::endl;
                        prepend(os, "|     ", gen_lv.second[i]);
                    }
                }
            }
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            return os;
        }
};




#endif